On the train from Rome to Florence, our seatmates were two teenagers from California (brother and sister) who'd had to leave their parents in Rome. Their father had been hospitalized the night before (possibly for appendicitis, although I don't think the diagnosis had been settled at this point.) The father was apparently okay, but the doctors had kept him in hospital for observation. So the parents sent the kids on ahead to the hotel they'd booked in Florence.
They were pretty self-assured, these two. I remember that they had their summer reading books with them; the girl was reading Slaughterhouse-Five.
Somewhere between Rome and Florence